https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:2902 Wed 24 Jul 2013 22:54:50 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23390 Wed 11 Apr 2018 14:11:03 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18363 Wed 11 Apr 2018 10:06:07 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24717 50 years old; n = 45). Thirteen (36.1%) reproductive-aged females were using the OCP. Participants had induced sputum cell counts measured and blood analysed for sex hormones and inflammatory markers. Results: Obese reproductive-aged females had higher sputum %neutrophils than nonobese reproductive-aged females (45.4 ± 24.3% vs 27.5 ± 17.5%, P = 0.016); however, there was no difference in sputum neutrophils in obese compared with nonobese males (P = 0.620) or older females (P = 0.087). Multiple linear regression analysis found testosterone and OCP use to be negative predictors of sputum %neutrophils, while C-reactive protein and IL-6 were positive predictors of sputum %neutrophils. BMI and age were not significant predictors in the multivariate model. Reproductive-aged females using the OCP had significantly lower sputum %neutrophils than those not using the OCP (23.2 ± 12.6% vs 42.1 ± 23.8%, P = 0.015). Conclusions: This study suggests that sex hormones and systemic inflammation may be mediating the obese-asthma phenotype. The observation that OCP use was associated with lower sputum %neutrophils in reproductive-aged females warrants further investigation.]]> Wed 09 Mar 2022 16:03:50 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36161 Thu 20 Feb 2020 14:45:19 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12888 Sat 24 Mar 2018 10:35:37 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8243 3.0 mg/l). Body composition and anthropometric measurements were recorded. Hs-CRP was analysed using immunoassays and fatty acids were measured by gas chromatography. Plasma hs-CRP concentration was negatively correlated with total n-3 fatty acids (P=0.05), eicosapentaenoic acid (EPA; P=0.002) and docosapentaenoic acid (DPA; P=0.01). The highest hs-CRP tertile (>3.0 mg/l) had significantly lower concentrations of total n-3 fatty acids, EPA and DPA, when compared with the other tertiles (P<0.05). This study provides evidence that in healthy individuals, plasma n-3 fatty acid concentration is inversely related to hs-CRP concentration, a surrogate marker of CVD risk.]]> Sat 24 Mar 2018 08:40:40 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8270 Sat 24 Mar 2018 08:33:28 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:2894 Sat 24 Mar 2018 08:32:49 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:2984 1 week) supplementation trials have been promising. However, the development of techniques to study isoprostanes in airway­lining fluid pave the way for further studies investigating the potential for antioxidant supplements to be used as routine therapy in asthma.]]> Sat 24 Mar 2018 08:27:56 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12427 2.25) children (33%) had an omega-3 index of < 4.0 (high risk) compared with non-obese children (BMI z-score < 2.25) (17%). Simultaneously, the number of children with a higher omega-3 index (6.0–8.0 lower risk) was lower in the obese (13%) versus non-obese children (25%, respectively). A moderate, but statistically significant correlation was found between O3I and fasting insulin level (r = −0.3, P = 0.03) and with homeostatic model assessment (HOMA) scores (r = −0.3, P = 0.04). Conclusion: The observed association between the omega-3 index, weight status and insulin resistance in children highlights the importance of omega-3 fatty acids in the prevention of obesity-related chronic diseases in later life. The results presented merits confirmation in a larger sample of obese children.]]> Sat 24 Mar 2018 08:17:46 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13283 Sat 24 Mar 2018 08:15:15 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20494 Sat 24 Mar 2018 07:59:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20580 Sat 24 Mar 2018 07:55:36 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21344 Sat 24 Mar 2018 07:51:24 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27120 Sat 24 Mar 2018 07:41:34 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25816 Sat 24 Mar 2018 07:34:38 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29529 Sat 24 Mar 2018 07:32:27 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25886 Sat 24 Mar 2018 07:25:52 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24376 Sat 24 Mar 2018 07:16:18 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39169 n = 38) or 2 g corn oil (CO) /day (control, n = 35) for 12 weeks in a double-blind randomised controlled trial. A fasting blood sample was collected at 0 and 12 weeks for assessment of IR, glucose and blood lipid profile. Sixty-eight participants completed the intervention. Compared with CO (n = 32), FO (n = 36) significantly reduced fasting insulin by -1.62 μIU/L (95%CI: -2.99, -0.26,) (p = 0.021) and HOMA-IR by -0.40 units (95%CI: -0.78, -0.02, p = 0.038). Higher insulin and HOMA-IR at baseline were associated with greater reductions in the FO group (p < 0.001). There was no interaction between sex and treatment for the change in insulin (p-interaction_{sex*treatment} = 0.816) or HOMA-IR (p-interaction_{sex*treatment} = 0.825). DHA-enriched FO reduces IR in adults with abdominal obesity, however, sex-dependent differences were not evident in this study.]]> Fri 20 May 2022 16:31:18 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32705 Fri 03 Dec 2021 10:33:11 AEDT ]]>